The dynamics of loss of heterozygosity events in genomes. Abhishek Dutta, Joseph Schacherer. Genomic instability is a hallmark of tumorigenesis, yet it also plays an essential role in evolution. Large-scale population genomics studies have highlighted the importance of loss of heterozygosity (LOH)…
Species-wide survey of the expressivity and complexity spectrum of traits in yeast. Andreas Tsouris, Téo Fournier, Anne Friedrich, Jing Hou, Maitreya J. Dunham, Joseph Schacherer. Assessing the complexity and expressivity of traits at the species level is an essential first step to better dissect…
The Laboratory of Excellence (LabEx) MitoCross announces the call for applications for two junior chairs in the field of research on mitochondria.
Nouvelle publication de l'équipe: Pervasive phenotypic impact of a large non-recombining introgressed region in yeast.
Nouvelle publication de l'équipe : High complexity and degree of genetic variation in Brettanomyces bruxellensis population.
Extensive impact of low-frequency variants on the phenotypic landscape at population-scale.
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose. Science Signaling 2019, doi: 10.1126/scisignal.aaw8000 Reshuffling yeast chromosomes with CRISPR/Cas9. PLoS Genet. 2019, doi: 10.1371/journal.pgen.1008332 RNAi…
Nouvelle publication en collaboration avec Philippe Marullo : Quantitative Trait Nucleotides impacting the technological performances of industrial Saccharomyces cerevisiae strains.
Nouvelle publication en collaboration avec l'équipe d'Eric Alani (Cornell University) : Incompatibilities in mismatch repair genes MLH1-PMS1 contribute to a wide range of mutation rates in human isolates of baker's yeast.
Les 1011 génomes de S. cerevisiae sont publiés dans Nature : Genome evolution across 1,011 Saccharomyces cerevisiae isolates
Deux nouvelles publications de l'équipe et en collaboration : Genetic backgrounds and hidden trait complexity in natural populations. Identification of a novel interspecific hybrid yeast from a metagenomic spontaneously inoculated beer sample using Hi-C.
Quatre nouvelles publications de l'équipe et en collaboration : Variation of the meiotic recombination landscape and properties over a broad evolutionary distance in yeasts. High-quality de novo genome assembly of the Dekkera bruxellensis yeast isolate using Nanopore MinION sequencing. …
Une nouvelle publication en collaboration avec Eric Alani : Mismatch Repair Incompatibilities in Diverse Yeast Populations.
Nouvelle publication en collaboration avec le Génoscope : de novo assembly and population genomic survey of natural yeast isolates with the Oxford Nanopore MinION sequencer.
Nouvelle publication de l'équipe dans Mol Biol Evol : Fitness trade-offs lead to suppressor tolerance in yeast.
Nouvelle publication de l’équipe dans Cell Reports : The hidden complexity of mendelian traits across natural yeast populations.
Une publication en collaboration avec Gilles Fischer : Reconstruction of ancestral chromosome architecture and gene repertoire reveals principles of genome evolution in a model yeast genus. et deux nouvelles publications : Beyond the simplicity of Mendelian inheritance. et : Species-wide survey…
Nouvelle publication de l'équipe : Differences in environmental stress response between yeasts is consistent with species-specific lifestyles.
Nouvelle publication de l'équipe dans G3 : Large-Scale Survey of Intraspecific Fitness and Cell Morphology Variation in a Protoploid Yeast Species.
